UNC0379 24 Well

UNC0379 24 WellUNC0379 is a selective, substrate competitive inhibitor of N lysine methyltransferase SETD8 with IC50 of 7. 9 ? M, high selectivity over 15 other methyltransferases.

reduced form of folic acid that is rapidly absorbed and extensively metabolized in the liver to other folic acid derivatives

is a pure heart rate lowering agent

It failed to inhibit PDHK4 at higher concentrations(>10 nM)

Manidipine is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive

4-Chloro-DL-phenylalanine acts pharmacologically to deplete endogenous levels of serotonin

a selective antibiotic that is effective on most bacteria

Varlitinib is a selective and potent ErbB1(EGFR) and ErbB2(HER2) inhibitor with IC50 of 7 nM and 2 nM

-ketoglutarate dehydrogenase in NCI-H460 cell line

VEGFR2(KDR)

-hydroxysteroid dehydrogenase used in the treatment of Cushing’s syndrome

HGFR and InsR

Lexibulin (CYT997) is a potent microtubule polymerization inhibitor with IC50 of 10-100 nM in cancer cell lines